Advanced isolated light chain amyloid cardiomyopathy with negative immunofixation and normal free light chain ratio
نویسندگان
چکیده
منابع مشابه
Serum free light chain analysis and urine immunofixation electrophoresis in patients with multiple myeloma.
PURPOSE Retrospective studies have shown that immunoassays measuring free light chains (FLC) in serum are useful for diagnosis and monitoring of multiple myeloma. This study prospectively evaluates the use of FLC assays and, for the first time, investigates the relationship between serum FLC concentrations and the presence and detectability of Bence Jones (BJ) proteins in the urine. PATIENTS ...
متن کاملIdentification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine.
BACKGROUND The diagnosis of systemic immunoglobulin light-chain (AL) amyloidosis requires demonstration of amyloid deposits in a tissue biopsy and amyloidogenic monoclonal light chains. The optimal strategy to identify the amyloidogenic clone has not been established. We prospectively assessed the diagnostic sensitivity of the serum free light chain (FLC) kappa/lambda ratio, a commercial serum ...
متن کاملSerum Free Light Chain Analysis
In healthy individuals, plasma cells originating from the bone marrow produce immunoglobulin molecules composed of two heavy chains and two light chains. There are two types of light chains in humans. The κ light chains are encoded by the immunoglobulin κ locus on chromosome 2 and λ light chains are encoded by the immunoglobulin λ locus on chromosome 22 [1]. During B lymphocyte development, the...
متن کاملClinical Comparisons of Two Free Light Chain Assays to Immunofixation Electrophoresis for Detecting Monoclonal Gammopathy
Free light chains (FLCs) are useful biomarkers for the diagnosis and monitoring of various plasma cell dyscrasias. One hundred fifty-seven samples from 120 patients for screening or monitoring of monoclonal gammopathy (MG) were included. The new N Latex FLC assays (Siemens Healthcare Diagnostics GmbH, Germany) were compared with the Freelite FLC assays (The Binding Site Ltd., UK) and the result...
متن کاملDiagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests.
This study aims to guide the integration of serum free light chain (sFLC) tests into clinical practice, including a new rapid test (Seralite® ). Blood and urine analysis from 5573 newly diagnosed myeloma patients identified 576 light chain only (LCO) and 60 non-secretory (NS) cases. Serum was tested by Freelite® and Seralite® at diagnosis, maximum response and relapse. 20% of LCO patients had u...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ESC Heart Failure
سال: 2021
ISSN: 2055-5822,2055-5822
DOI: 10.1002/ehf2.13381